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Publication type: Journal Article
Document type: Proceedings Paper

Year: 1998

Author(s): Pescovitz, MD; Book, BK; Aasted, B; Dominguez, J; Bullido, R; Trebichavsky, I; Novikov, B; Valpotic, I; Tomaskovic, M; Nielsen, J; Arn, S; Sachs, DH; Lunney, JK; Boyd, PC; Walker, J; Lee, R; Saalmüller, A

Title: Analyses of monoclonal antibodies reacting with porcine CD5: results from the Second International Swine CD Workshop.

Source: Vet Immunol Immunopathol (60), 3-4 269-273.

Authors Vetmeduni Vienna:

Saalmüller Armin

Among the 57 monoclonal antibodies analyzed within the T-cell group, three mAbs fell within cluster T13 including the CD5a standard b53b7 (No. 174). The two new mAbs 1H6/8 (No. 058) and BB6-9G12 (No, 166) both precipitated 55 and 60 kDa proteins that were of similar molecular weights as the standard. Staining patterns on the various cell types were similar. Both new antibodies inhibited the binding of the CD5a reference mAbs b53b7 to peripheral lymphocytes. These mAbs, therefore both react with the CD5a epitope bringing the number of anti-porcine CD5 mAbs to eight, all of which appear to recognize the same epitope. (C) 1998 Elsevier Science B.V.

Keywords Pubmed: Animals - : Antibodies, Monoclonal - analysis : Antigen-Antibody Reactions - analysis : Antigens, CD5 - metabolism : Binding Sites, Antibody - metabolism : Binding, Competitive - immunology : Flow Cytometry - veterinary : Lymphocyte Subsets - immunology : Precipitin Tests - veterinary : Swine - immunology

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