Feline panleukopenia is still considered an important disease, although some time has passed since identification of its aetiology as a virus in 1932. In the past, prognosis has often been described as very poor with up to 90 % mortality in diseased cats; however, little is known about prognostic factors in feline panleukopenia or the current mortality rate in patients treated with intensive care. In this retrospective study of 73 cats with feline panleukopenia, animals with anorexia, hypothermia, reduced skin elasticity, poor nutritional condition, lymphopenia, thrombocytopenia or hypoalbumenaemia had a significantly higher probability to die. Adjuvant application of antibodies against panleukopeniavirus, rhinotracheitisvirus and calicivirus (Feliserin (R)) improved the chance of survival. In contrast, treatment with either a single or two different antibiotics had no influence on survival rate. The average duration of hospitalization was five days, and mean costs for the owners of surviving cats amounted to 579 Euro. The mortality rate of 61 intensively treated cats was 49 %, indicating a survival rate of 51 %. Thus with aggressive treatment, the prognosis seems to be more-favourable than described in the past. Owners informed about this fact might be more willing to attempt treatment for their cats suffering from parvovirus infection.