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Selected Publication:

Publication type: Journal Article
Document type: Full Paper

Year: 2013

Author(s): Bakonyi, T; Ferenczi, E; Erdélyi, K; Kutasi, O; Csörgő, T; Seidel, B; Weissenböck, H; Brugger, K; Bán, E; Nowotny, N

Title: Explosive spread of a neuroinvasive lineage 2 West Nile virus in Central Europe, 2008/2009.

Source: Vet Microbiol. 2013; 165(1-2):61-70



Authors Vetmeduni Vienna:

Bakonyi Tamas
Brugger Katharina
Nowotny Norbert
Weissenböck Herbert

Vetmed Research Units
Institute of Pathology
Institute of Virology
Institute of Food Safety, Food Technology and Veterinary Public Health, Unit of Veterinary Public Health and Epidemiology


Abstract:
For the first time outside sub-Saharan Africa, a lineage 2 West Nile virus (WNV) emerged in Hungary in 2004. It caused sporadic cases of encephalitis in goshawks (Accipiter gentilis), other predatory birds, and in mammals. As a consequence, a surveillance program was initiated in Hungary and in Austria, which included virological, molecular, serological and epidemiological investigations in human beings, birds, horses, and mosquitoes. The virus strain became endemic to Hungary, however only sporadic cases of infections were observed between 2004 and 2007. Unexpectedly, explosive spread of the virus was noted in 2008, when neuroinvasive West Nile disease (WND) was diagnosed all over Hungary in dead goshawks and other birds of prey (n=25), in horses (n=12), and humans (n=22). At the same time this virus also spread to the eastern part of Austria, where it was detected in dead wild birds (n=8). In 2009, recurrent WND outbreaks were observed in Hungary and Austria, in wild birds, horses, and humans in the same areas. Virus isolates of both years exhibited closest genetic relationship to the lineage 2 WNV strain which emerged in 2004. As we know today, the explosive spread of the lineage 2 WNV in 2008 described here remained not restricted to Hungary and Austria, but this virus dispersed further to the south to various Balkan states and reached northern Greece, where it caused the devastating neuroinvasive WND outbreak in humans in 2010.

Keywords Pubmed: Adolescent
Adult
Aged
Animals
Austria/epidemiology
Base Sequence
Bird Diseases/epidemiology
Bird Diseases/virology*
Birds
Child
Culicidae/virology
Female
Horse Diseases/epidemiology
Horse Diseases/virology*
Horses
Humans
Hungary/epidemiology
Male
Middle Aged
Molecular Sequence Data
Phylogeny
West Nile Fever/epidemiology
West Nile Fever/veterinary*
West Nile Fever/virology
West Nile virus/genetics
West Nile virus/isolation & purification
West Nile virus/physiology*
Young Adult


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