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Type of publication: Journal Article
Type of document: Full Paper

Year: 2013

Authors: Suvorov, A; Nolte, V; Pandey, RV; Franssen, SU; Futschik, A; Schlötterer, C

Title: Intra-specific regulatory variation in Drosophila pseudoobscura.

Source: PLoS One. 2013; 8(12):e83547

Authors Vetmeduni Vienna:

Franssen Susanne
Futschik Andreas
Nolte Viola
Pandey Ram Vinay
Schlötterer Christian

Vetmed Research Units
Institute of Population Genetics
Platform Bioinformatics and Biostatistics

Project(s): Evolution of gene expression in Drosophila

It is generally accepted that gene regulation serves an important role in determining the phenotype. To shed light on the evolutionary forces operating on gene regulation, previous studies mainly focused on the expression differences between species and their inter-specific hybrids. Here, we use RNA-Seq to study the intra-specific distribution of cis- and trans-regulatory variation in Drosophila pseudoobscura. Consistent with previous results, we find almost twice as many genes (26%) with significant trans-effects than genes with significant cis-effects (18%). While this result supports the previous suggestion of a larger mutational target of trans-effects, we also show that trans-effects may be subjected to purifying selection. Our results underline the importance of intra-specific analyses for the understanding of the evolution of gene expression.

Keywords Pubmed: Alleles
Biological Evolution
Drosophila Proteins/genetics*
Gene Expression Profiling
Gene Expression Regulation*
Inheritance Patterns
Molecular Sequence Annotation
Species Specificity

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