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Selected Publication:

Publication type: Journal Article
Document type: Review

Year: 2014

Author(s): Mair, KH; Sedlak, C; Käser, T; Pasternak, A; Levast, B; Gerner, W; Saalmüller, A; Summerfield, A; Gerdts, V; Wilson, HL; Meurens, F

Title: The porcine innate immune system: an update.

Source: Dev Comp Immunol. 2014; 45(2):321-343



Authors Vetmeduni Vienna:

Gerner Wilhelm
Mair Kerstin
Saalmüller Armin
Sedlak Corinna

Vetmed Research Units
Institute of Immunology


Abstract:
Over the last few years, we have seen an increasing interest and demand for pigs in biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of their anatomy, genetics, and physiology, and often are the model of choice for the assessment of novel vaccines and therapeutics in a preclinical stage. However, the pig as a model has much more to offer, and can serve as a model for many biomedical applications including aging research, medical imaging, and pharmaceutical studies to name a few. In this review, we will provide an overview of the innate immune system in pigs, describe its anatomical and physiological key features, and discuss the key players involved. In particular, we compare the porcine innate immune system to that of humans, and emphasize on the importance of the pig as model for human disease.

Keywords Pubmed: Animals
Immunity, Innate*
Inflammation/immunology
Receptors, Cytoplasmic and Nuclear/metabolism
Receptors, Pattern Recognition/immunology
Sus scrofa/immunology*
Swine/immunology
Swine Diseases/immunology


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