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Type of publication: Journal Article
Type of document: Full Paper

Year: 2014

Authors: Stremnitzer, C; Manzano-Szalai, K; Starkl, P; Willensdorfer, A; Schrom, S; Singer, J; Reichart, U; Akira, S; Jensen-Jarolim, E

Title: Epicutaneously applied Der p 2 induces a strong TH 2-biased antibody response in C57BL/6 mice, independent of functional TLR4.

Source: Allergy. 2014; 69(6):741-751

Authors Vetmeduni Vienna:

Jensen-Jarolim Erika
Reichart Ursula

Vetmed Research Units
Biomodels Austria
Messerli Research Institute, Comparative Medicine
Institute of Animal Breeding and Genetics, Unit of Molecular Genetics

The major house dust mite allergen Der p 2 is a structural and functional homologue of MD-2 within the TLR4-CD14-MD-2 complex. An asthma mouse model in TLR4-deficient mice recently suggested that the allergic immune response against Der p 2 is solely dependent on TLR4 signaling. We investigated whether similar mechanisms are important for Der p 2 sensitization via the skin.

Keywords Pubmed: Animals
Antibody Formation/immunology*
Antibody Specificity/immunology
Antigens, Dermatophagoides/administration & dosage
Antigens, Dermatophagoides/immunology*
Antigens, Surface/metabolism
Arthropod Proteins/administration & dosage
Arthropod Proteins/immunology*
Immunoglobulin E/blood
Immunoglobulin E/immunology
Immunoglobulin G/blood
Immunoglobulin G/immunology
Lectins, C-Type/metabolism
Mannose-Binding Lectins/metabolism
Mice, Inbred C57BL
Mice, Knockout
Th2 Cells/immunology*
Th2 Cells/metabolism*
Toll-Like Receptor 4/genetics
Toll-Like Receptor 4/metabolism*

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