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Type of publication: Journal Article
Type of document: Full Paper

Year: 2014

Authors: Stremnitzer, C; Manzano-Szalai, K; Starkl, P; Willensdorfer, A; Schrom, S; Singer, J; Reichart, U; Akira, S; Jensen-Jarolim, E

Title: Epicutaneously applied Der p 2 induces a strong TH 2-biased antibody response in C57BL/6 mice, independent of functional TLR4.

Source: Allergy. 2014; 69(6):741-751



Authors Vetmeduni Vienna:

Jensen-Jarolim Erika
Reichart Ursula

Vetmed Research Units
Biomodels Austria
Messerli Research Institute, Comparative Medicine
Institute of Animal Breeding and Genetics, Unit of Molecular Genetics


Abstract:
The major house dust mite allergen Der p 2 is a structural and functional homologue of MD-2 within the TLR4-CD14-MD-2 complex. An asthma mouse model in TLR4-deficient mice recently suggested that the allergic immune response against Der p 2 is solely dependent on TLR4 signaling. We investigated whether similar mechanisms are important for Der p 2 sensitization via the skin.

Keywords Pubmed: Animals
Antibody Formation/immunology*
Antibody Specificity/immunology
Antigens, Dermatophagoides/administration & dosage
Antigens, Dermatophagoides/immunology*
Antigens, Surface/metabolism
Arthropod Proteins/administration & dosage
Arthropod Proteins/immunology*
Cytokines/metabolism
Female
Immunoglobulin E/blood
Immunoglobulin E/immunology
Immunoglobulin G/blood
Immunoglobulin G/immunology
Lectins, C-Type/metabolism
Lipopolysaccharides/immunology
Mannose-Binding Lectins/metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Skin/immunology
Skin/metabolism
Skin/pathology
Spleen/cytology
Spleen/immunology
Spleen/metabolism
Th2 Cells/immunology*
Th2 Cells/metabolism*
Toll-Like Receptor 4/genetics
Toll-Like Receptor 4/metabolism*


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