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Publication type: Journal Article
Document type: Full Paper

Year: 2014

Author(s): Haas, E; Rütgen, BC; Gerner, W; Richter, B; Tichy, A; Galler, A; Bilek, A; Thalhammer, JG; Saalmüller, A; Luckschander-Zeller, N

Title: Phenotypic characterization of canine intestinal intraepithelial lymphocytes in dogs with inflammatory bowel disease.

Source: J Vet Intern Med. 2014; 28(6):1708-1715



Authors Vetmeduni Vienna:

Bilek Andrea
Galler Alexandra
Gerner Wilhelm
Haas Eva
Luckschander-Zeller Nicole
Richter Barbara
Rütgen Barbara
Saalmüller Armin
Thalhammer Johann
Tichy Alexander

Vetmed Research Units
Clinical Pathology Platform
University Clinic for Small Animals, Clinical Unit of Internal Medicine Small Animals
Institute of Immunology
Institute of Pathology
Platform Bioinformatics and Biostatistics


Project(s): Canine chronic enteropathies


Abstract:
Many dogs suffering from inflammatory bowel disease (IBD) are presented to veterinary clinics. These patients are diagnosed based on a history of chronic gastrointestinal signs and biopsy-confirmed histopathologic intestinal inflammation. Intestinal intraepithelial lymphocytes (IEL) are part of the first line of defense in the gastrointestinal immune system. Alterations in IEL subsets may play a role in the pathogenesis of IBD.


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