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Type of publication: Journal Article
Type of document: Review Article

Year: 2015

Authors: Schlötterer, C

Title: Genes from scratch--the evolutionary fate of de novo genes.

Source: Trends Genet. 2015; 31(4):215-219

Authors Vetmeduni Vienna:

Schlötterer Christian

Vetmed Research Units
Institute of Population Genetics

Project(s): Evolution of gene expression in Drosophila

ERC ADG: The architecture of adaptation

Wolbachia infection Dynamics in evolving Drosophila populations

Although considered an extremely unlikely event, many genes emerge from previously noncoding genomic regions. This review covers the entire life cycle of such de novo genes. Two competing hypotheses about the process of de novo gene birth are discussed as well as the high death rate of de novo genes. Despite the high death rate, some de novo genes are retained and remain functional, even in distantly related species, through their integration into gene networks. Further studies combining gene expression with ribosome profiling in multiple populations across different species will be instrumental for an improved understanding of the evolutionary processes operating on de novo genes.

Keywords Pubmed: Animals
Biological Evolution
Evolution, Molecular*

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