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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2013

Authors: Wressnigg, N; Pöllabauer, EM; Aichinger, G; Portsmouth, D; Löw-Baselli, A; Fritsch, S; Livey, I; Crowe, BA; Schwendinger, M; Brühl, P; Pilz, A; Dvorak, T; Singer, J; Firth, C; Luft, B; Schmitt, B; Zeitlinger, M; Müller, M; Kollaritsch, H; Paulke-Korinek, M; Esen, M; Kremsner, PG; Ehrlich, HJ; Barrett, PN

Title: Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial.

Source: Lancet Infect Dis (13), 8 680-689.



Authors Vetmeduni Vienna:

Firth Clair


Abstract:
Lyme borreliosis is caused by Borrelia burgdorferi sensu stricto in the USA and by several Borrelia species in Europe and Asia, but no human vaccine is available. We investigated the safety and immunogenicity of adjuvanted and non-adjuvanted vaccines containing protective epitopes from Borrelia species outer surface protein A (OspA) serotypes in healthy adults.

Keywords Pubmed: Adjuvants, Immunologic/adverse effects*
Adult
Antigens, Surface/adverse effects*
Antigens, Surface/immunology*
Bacterial Outer Membrane Proteins/adverse effects*
Bacterial Outer Membrane Proteins/immunology*
Bacterial Vaccines/adverse effects*
Bacterial Vaccines/immunology*
Borrelia burgdorferi/immunology*
Double-Blind Method
Female
Headache/chemically induced
Humans
Immunoglobulin G/blood
Lipoproteins/adverse effects*
Lipoproteins/immunology*
Lyme Disease Vaccines/adverse effects*
Lyme Disease Vaccines/immunology*
Male
Middle Aged
Pain/chemically induced
Young Adult


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