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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2010

Authors: Pöllabauer, EM; Fritsch, S; Pavlova, BG; Löw-Baselli, A; Firth, C; Koska, M; Maritsch, F; Barrett, PN; Ehrlich, HJ

Title: Clinical evaluation to determine the appropriate paediatric formulation of a tick-borne encephalitis vaccine.

Source: Vaccine. 2010; 28(29):4558-4565

Authors Vetmeduni Vienna:

Firth Clair

Two dose-finding studies and one open label safety study with a paediatric FSME-IMMUN formulation were conducted in children and adolescents aged 1-15 years (N=3697). The 1.2 microg antigen dose was identified as the optimal dose, inducing high seroconversion rates following the primary vaccination series. Adolescents (aged 12-15 years) vaccinated with the optimal paediatric dose (1.2 microg) attained similarly high seroprotective rates to adults (aged 16-35 years) vaccinated with the 2.4 microg formulation of FSME-IMMUN. We concluded that the FSME-IMMUN paediatric vaccine formulation is safe and highly immunogenic, not only for children <12 years, but also for adolescents <16 years.

Keywords Pubmed: Adolescent
Antibodies, Viral/blood
Child, Preschool
Dosage Forms
Dose-Response Relationship, Immunologic
Double-Blind Method
Encephalitis Viruses, Tick-Borne/immunology
Encephalitis, Tick-Borne/prevention & control*
Immunoglobulin G/blood
Viral Vaccines/administration & dosage*
Viral Vaccines/adverse effects
Viral Vaccines/immunology
Young Adult

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