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Selected Publication:

Type of publication: Journal Article
Type of document: Review

Year: 2016

Authors: Turner, SD; Lamant, L; Kenner, L; Brugières, L

Title: Anaplastic large cell lymphoma in paediatric and young adult patients.

Source: Br J Haematol. 2016; 173(4):560-572

Authors Vetmeduni Vienna:

Kenner Lukas

Vetmed Research Units
Institute of Pathology, Pathology of Laboratory Animals

Anaplastic large cell lymphoma (ALCL) is a heterogeneous disease of debateable origin that, in children, is largely anaplastic lymphoma kinase (ALK) positive with aberrant ALK activity induced following the formation of chromosomal translocations. Whilst the survival rates for this disease are relatively high, a significant proportion (20-40%) of patients suffer disease relapse, in some cases on multiple occasions and therefore suffer the toxic side-effects of combination chemotherapy. Traditionally, patients are treated with a combination of agents although recent data from relapse patients have suggested that low risk patients might benefit from single agent vinblastine and, going forward, the addition of ALK inhibitors to the therapeutic regimen may have beneficial consequences. There are also a plethora of other drugs that might be advantageous to patients with ALCL and many of these have been identified through laboratory research although the decision as to which drugs to implement in trials will not be trivial.© 2016 John Wiley & Sons Ltd.

Keywords Pubmed: Adolescent
Anaplastic Lymphoma Kinase
Antineoplastic Agentstherapeutic use
Child, Preschool
Lymphoma, Large-Cell, Anaplasticdiagnosisdrug therapymortalitypathology
Middle Aged
Molecular Targeted Therapy
Receptor Protein-Tyrosine Kinasesantagonists & inhibitors
Young Adult

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