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Type of publication: Journal Article
Type of document: Full Paper

Year: 2017

Authors: Wolfesberger, B; Skor, O; Hammer, SE; Flickinger, I; Kleiter, M; Rütgen, BC; Schwendenwein, I; Tichy, A; Hittmair, KM; Degasperi, B; Fuchs-Baumgartinger, A

Title: Does categorisation of lymphoma subtypes according to the World Health Organization classification predict clinical outcome in cats?

Source: J Feline Med Surg. 2017; 19(8):897-906



Authors Vetmeduni Vienna:

Degasperi Brigitte
Flickinger Irene
Fuchs-Baumgartinger Andrea
Hammer Sabina
Hittmair Katharina
Kleiter Miriam
Rütgen Barbara
Schwendenwein Ilse
Skor Ondrej
Tichy Alexander
Wolfesberger Birgitt

Vetmed Research Units
Clinical Pathology Platform
University Clinic for Small Animals, Clinical Unit of Diagnostic Imaging
University Clinic for Small Animals, Clinical Unit of Internal Medicine Small Animals
University Clinic for Small Animals, Clinical Unit of Small Animal Surgery
Institute of Immunology
Institute of Pathology
Platform Bioinformatics and Biostatistics
Radiooncology and Nuclear Medicine Platform


Abstract:
Objectives The purpose of this study was to specify lymphoma subtypes according to the World Health Organization (WHO) classification in a group of cats and to investigate their potential prognostic value. Methods Records of cats from the University of Veterinary Medicine Vienna suffering from lymphoma were reviewed in this retrospective study. To diagnose various subtypes specified in the WHO classification, histopathological and immunohistochemical examinations, as well as clonality assays in some cases, were performed. Results Of the 30 cats included in this study and classified according to the WHO guidelines, peripheral T-cell lymphoma was the most prevalent lymphoma subtype (37% of cases; n = 11), followed by diffuse large B-cell (23%; n = 7), intestinal T-cell (10%; n = 3), T-cell-rich B-cell (10%; n = 3), large granular lymphocytic (7%; n = 2), anaplastic large T-cell (7%; n = 2), B-cell small lymphocytic (3%; n = 1) and T-cell angiotropic lymphoma (3%; n = 1). The median survival time (MST) was 5.4 months (range 6 days to 2.2 years), with two cats still alive after 1.7 and 2.0 years, respectively. Treating cats prior to chemotherapy with glucocorticoids did not worsen their prognosis. Adding to chemotherapy, radiotherapy or surgery did not improve the clinical outcome. We observed that patients with intestinal T-cell lymphoma lived significantly longer (MST 1.7 years) than those with a diffuse large B-cell (MST 4.5 months) or peripheral T-cell lymphoma (MST 6.1 months). Cats with T-cell-rich B-cell lymphoma survived significantly longer (MST 1.2 years) than those with a diffuse large B-cell lymphoma. Conclusions and relevance A detailed diagnosis of feline lymphoma can be obtained by allocating different subtypes according to the WHO classification. From the eight detected lymphoma subtypes, two, intestinal T-cell lymphoma and T-cell-rich B-cell lymphoma, showed promising survival times in cats.

Keywords Pubmed: Animals
Austriaepidemiology
Cat Diseasesclassificationmortalitypathology
Cats
Female
Lymphomaclassificationmortalityveterinary
Male
Neoplasm Staging
Prevalence
Prognosis
Retrospective Studies
Survival Analysis
World Health Organization

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