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Publication type: Journal Article
Document type: Full Paper

Year: 2016

Author(s): Newman, MA; Zebeli, Q; Velde, K; GrĂ¼ll, D; Molnar, T; Kandler, W; Metzler-Zebeli, BU

Title: Enzymatically Modified Starch Favorably Modulated Intestinal Transit Time and Hindgut Fermentation in Growing Pigs.

Source: PLoS One. 2016; 11(12):e0167784



Authors Vetmeduni Vienna:

Metzler-Zebeli Barbara
Newman Monica
Velde Karsten
Zebeli Qendrim

Vetmed Research Units
Clinical Unit of Equine Surgery
Institute of Animal Nutrition and Functional Plant Compounds
University Clinic for Swine


Project(s): Establishment of a reliable in vivo model for the classification of the health-promoting effects of carbohydrates


Abstract:
Aside from being used as stabilizing agents in many processed foods, chemically modified starches may act as functional dietary ingredients. Therefore, development of chemically modified starches that are less digestible in the upper intestinal segments and promote fermentation in the hindgut receives considerable attention. This study aimed to investigate the impact of an enzymatically modified starch (EMS) on nutrient flow, passage rate, and bacterial activity at ileal and post-ileal level. Eight ileal-cannulated growing pigs were fed 2 diets containing 72% purified starch (EMS or waxy cornstarch as control) in a cross-over design for 10 d, followed by a 4-d collection of feces and 2-d collection of ileal digesta. On d 17, solid and liquid phase markers were added to the diet to determine ileal digesta flow for 8 h after feeding. Reduced small intestinal digestion after the consumption of the EMS diet was indicated by a 10%-increase in ileal flow and fecal excretion of dry matter and energy compared to the control diet (P<0.05). Moreover, EMS feeding reduced ileal transit time of both liquid and solid fractions compared to the control diet (P<0.05). The greater substrate flow to the large intestine with the EMS diet increased the concentrations of total and individual short-chain fatty acids (SCFA) in feces (P<0.05). Total bacterial 16S rRNA gene abundance was not affected by diet, whereas the relative abundance of the Lactobacillus group decreased (P<0.01) by 50% and of Enterobacteriaceae tended (P<0.1) to increase by 20% in ileal digesta with the EMS diet compared to the control diet. In conclusion, EMS appears to resemble a slowly digestible starch by reducing intestinal transit and increasing SCFA in the distal large intestine.

Keywords Pubmed: Animal Feed*/analysis
Animal Nutritional Physiological Phenomena
Animals
Digestion
Fermentation*
Functional Food/analysis
Gastrointestinal Transit*
Ileum/microbiology
Ileum/physiology
Intestines/microbiology
Intestines/physiology*
Male
Starch/analogs & derivatives*
Starch/metabolism*
Swine/growth & development
Swine/physiology*


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