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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2016

Authors: Veith, VK; Quigley, C; Treue, S

Title: A Pressure Injection System for Investigating the Neuropharmacology of Information Processing in Awake Behaving Macaque Monkey Cortex.

Source: J Vis Exp. 2016;

Authors Vetmeduni Vienna:

Quigley Cliodhna

The top-down modulation of feed-forward cortical information processing is functionally important for many cognitive processes, including the modulation of sensory information processing by attention. However, little is known about which neurotransmitter systems are involved in such modulations. A practical way to address this question is to combine single-cell recording with local and temporary neuropharmacological manipulation in a suitable animal model. Here we demonstrate a technique combining acute single-cell recordings with the injection of neuropharmacological agents in the direct vicinity of the recording electrode. The video shows the preparation of the pressure injection/recording system, including preparation of the substance to be injected. We show a rhesus monkey performing a visual attention task and the procedure of single-unit recording with block-wise pharmacological manipulations.

Keywords Pubmed: Animals
Attention/drug effects
Cerebral Cortex/drug effects
Cerebral Cortex/physiology*
Cognition/drug effects
Macaca mulatta
Scopolamine Hydrobromide/administration & dosage*
Wakefulness/drug effects

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