University of Veterinary Medicine Vienna - Research portal

Diagrammed Link to Homepage University of Veterinary Medicine, Vienna

Selected Publication:

Publication type: Journal Article
Document type: Full Paper

Year: 2016

Author(s): Falgenhauer, L; Imirzalioglu, C; Ghosh, H; Gwozdzinski, K; Schmiedel, J; Gentil, K; Bauerfeind, R; Kampfer, P; Seifert, H; Michael, GB; Schwarz, S; Pfeifer, Y; Werner, G; Pietsch, M; Roesler, U; Guerra, B; Fischer, J; Sharp, H; Kasbohrer, A; Goesmann, A; Hille, K; Kreienbrock, L; Chakraborty, T

Title: Circulation of clonal populations of fluoroquinolone-resistant CTX-M-15-producing Escherichia coli ST410 in humans and animals in Germany

Source: Int J Antimicrob Ag. 2016; 47(6): 457-465.

Authors Vetmeduni Vienna:

Käsbohrer Annemarie

Multidrug-resistant Escherichia coli encoding CTX-M-type extended-spectrum beta-lactamases (ESBLs) are isolated in increasing numbers from humans, companion animals and livestock, raising concern regarding the exchange and spread of isolates in these populations. In this study, whole-genome sequencing of CTX-M-15-producing E. coli isolates recently sampled from humans, companion animals, livestock and farm environments was performed. In total, 26 different sequence types (STs) were detected, of which ST410 was the most frequent and was the only ST present in all populations studied. Five clades (designated A-E) were detected within the ST410 isolates. In particular, isolates of clade B were present in all four populations and had core genomes that differed by less than 70 single nucleotide polymorphisms (SNPs). Isolates of clades B and C were also clonally marked, exhibiting identical chromosomal insertions of bla(CTX-M-15) at distinct loci. These data provide strong evidence for the clonal dissemination of specific clades of CTX-M-15-producing E. coli ST410 in human and animal populations. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

© University of Veterinary Medicine ViennaHelp and Downloads