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Type of publication: Journal Article
Type of document: Full Paper

Year: 2017

Authors: Goymann, W; Lupi, S; Kaiya, H; Cardinale, M; Fusani, L

Title: Ghrelin affects stopover decisions and food intake in a long-distance migrant.

Source: Proc Natl Acad Sci U S A. 2017; 114(8):1946-1951



Authors Vetmeduni Vienna:

Fusani Leonida
Lupi Sara

Vetmed Research Units
Konrad Lorenz Institute of Ethology, Unit of Ornithology


Abstract:
Billions of birds migrate long distances to either reach breeding areas or to spend the winter at more benign places. On migration, most passerines frequently stop over to rest and replenish their fuel reserves. To date, we know little regarding how they decide that they are ready to continue their journey. What physiological signals tell a bird's brain that its fuel reserves are sufficient to resume migration? A network of hormones regulates food intake and body mass in vertebrates, including the recently discovered peptide hormone, ghrelin. Here, we show that ghrelin reflects body condition and influences migratory behavior of wild birds. We measured ghrelin levels of wild garden warblers (Sylvia borin) captured at a stopover site. Further, we manipulated blood concentrations of ghrelin to test its effects on food intake and migratory restlessness. We found that acylated ghrelin concentrations of garden warblers with larger fat scores were higher than those of birds without fat stores. Further, injections of unacylated ghrelin decreased food intake and increased migratory restlessness. These results represent experimental evidence that appetite-regulating hormones control migratory behavior. Our study lays a milestone in migration physiology because it provides the missing link between ecologically dependent factors such as condition and timing of migration. In addition, it offers insights in the regulation of the hormonal system controlling food intake and energy stores in vertebrates, whose disruption causes eating disorders and obesity.

Keywords Pubmed: Animal Migrationphysiology
Animals
Appetite Regulationphysiology
Body Composition
Feeding Behaviorphysiology
Ghrelinphysiology
Seasons
Songbirdsphysiology

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