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Publication type: Journal Article
Document type: Full Paper

Year: 2017

Author(s): Newman, MA; Zebeli, Q; Eberspächer, E; Grüll, D; Molnar, T; Metzler-Zebeli, BU

Title: Transglycosylated Starch Improves Insulin Response and Alters Lipid and Amino Acid Metabolome in a Growing Pig Model.

Source: Nutrients. 2017; 9(3):



Authors Vetmeduni Vienna:

Eberspächer-Schweda Eva
Metzler-Zebeli Barbara
Newman Monica
Zebeli Qendrim

Vetmed Research Units
Clinical Unit of Anaesthesiology and Perioperative Intensive-Care Medicine
Institute of Animal Nutrition and Functional Plant Compounds
University Clinic for Swine


Project(s): Establishment of a reliable in vivo model for the classification of the health-promoting effects of carbohydrates


Abstract:
Due to the functional properties and physiological effects often associated with chemically modified starches, significant interest lies in their development for incorporation in processed foods. This study investigated the effect of transglycosylated cornstarch (TGS) on blood glucose, insulin, and serum metabolome in the pre- and postprandial phase in growing pigs. Eight jugular vein-catheterized barrows were fed two diets containing 72% purified starch (waxy cornstarch (CON) or TGS). A meal tolerance test (MTT) was performed with serial blood sampling for glucose, insulin, lipids, and metabolome profiling. TGS-fed pigs had reduced postprandial insulin (p < 0.05) and glucose (p < 0.10) peaks compared to CON-fed pigs. The MTT showed increased (p < 0.05) serum urea with TGS-fed pigs compared to CON, indicative of increased protein catabolism. Metabolome profiling showed reduced (p < 0.05) amino acids such as alanine and glutamine with TGS, suggesting increased gluconeogenesis compared to CON, probably due to a reduction in available glucose. Of all metabolites affected by dietary treatment, alkyl-acyl-phosphatidylcholines and sphingomyelins were generally increased (p < 0.05) preprandially, whereas diacyl-phosphatidylcholines and lysophosphatidylcholines were decreased (p < 0.05) postprandially in TGS-fed pigs compared to CON. In conclusion, TGS led to changes in postprandial insulin and glucose metabolism, which may have caused the alterations in serum amino acid and phospholipid metabolome profiles.

Keywords Pubmed: Amino Acids/blood
Amino Acids/chemistry*
Animals
Blood Glucose/metabolism
Diet
Insulin/blood*
Lipid Metabolism*
Lysophosphatidylcholines/metabolism
Male
Metabolome*
Models, Animal
Phosphatidylcholines/metabolism
Postprandial Period
Sphingomyelins/metabolism
Starch/chemistry*
Swine
Urea/blood


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