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Type of publication: Journal Article
Type of document: Full Paper

Year: 2018

Authors: Bergman, J; Betancourt, AJ; Vogl, C

Title: Transcription-Associated Compositional Skews in Drosophila Genes.

Source: Genome Biol Evol. 2018; 10(1):269-275

Authors Vetmeduni Vienna:

Bergman Juraj
Betancourt Andrea Jean
Vogl Claus

Vetmed Research Units
Institute of Population Genetics
Institute of Animal Breeding and Genetics, Unit of Molecular Genetics

Project(s): Population Genetics

In many organisms, local deviations from Chargaff's second parity rule are observed around replication and transcription start sites and within intron sequences. Here, we use expression data as well as a whole-genome data set of nearly 200 haplotypes to investigate such compositional skews in Drosophila melanogaster genes. We find a positive correlation between compositional skew and gene expression, comparable in strength to similar correlations between expression levels and genome-wide sequence features. This correlation is relatively stronger for germline, compared with somatic expression, consistent with the process of transcription-associated mutation bias. We also inferred mutation rates from alleles segregating at low frequencies in short introns, and show that, whereas the overall GC content of short introns does not conform to the equilibrium expectation, the level of the observed deviation from the second parity rule is generally consistent with the inferred rates.© The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Keywords Pubmed: Animals
Base Composition
Drosophila melanogastergenetics
Evolution, Molecular
Genes, Insect
Mutation Accumulation
Transcription, Genetic

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