University of Veterinary Medicine Vienna - Research portal

Diagrammed Link to Homepage University of Veterinary Medicine, Vienna

Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2018

Authors: Bergman, J; Schrempf, D; Kosiol, C; Vogl, C

Title: Inference in population genetics using forward and backward, discrete and continuous time processes.

Source: J Theor Biol. 2018; 439:166-180

Authors Vetmeduni Vienna:

Bergman Juraj
Kosiol Carolin
Schrempf Dominik
Vogl Claus

Vetmed Research Units
Institute of Population Genetics
Institute of Animal Breeding and Genetics, Unit of Molecular Genetics

Project(s): Empirical codon models for comparative re-sequencing data

Population Genetics

Genome-wide Molecular Dating

A central aim of population genetics is the inference of the evolutionary history of a population. To this end, the underlying process can be represented by a model of the evolution of allele frequencies parametrized by e.g., the population size, mutation rates and selection coefficients. A large class of models use forward-in-time models, such as the discrete Wright-Fisher and Moran models and the continuous forward diffusion, to obtain distributions of population allele frequencies, conditional on an ancestral initial allele frequency distribution. Backward-in-time diffusion processes have been rarely used in the context of parameter inference. Here, we demonstrate how forward and backward diffusion processes can be combined to efficiently calculate the exact joint probability distribution of sample and population allele frequencies at all times in the past, for both discrete and continuous population genetics models. This procedure is analogous to the forward-backward algorithm of hidden Markov models. While the efficiency of discrete models is limited by the population size, for continuous models it suffices to expand the transition density in orthogonal polynomials of the order of the sample size to infer marginal likelihoods of population genetic parameters. Additionally, conditional allele trajectories and marginal likelihoods of samples from single populations or from multiple populations that split in the past can be obtained. The described approaches allow for efficient maximum likelihood inference of population genetic parameters in a wide variety of demographic scenarios.Copyright © 2017 Elsevier Ltd. All rights reserved.

Keywords Pubmed: Algorithms
Biological Evolution
Gene Frequency
Genetics, Populationmethods
Likelihood Functions
Markov Chains
Models, Genetic
Population Density

© University of Veterinary Medicine ViennaHelp and DownloadsAccessibility statement