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Type of publication: Journal Article
Type of document: Full Paper

Year: 2018

Authors: Wolfesberger, B; Fuchs-Baumgartinger, A; Greß, V; Hammer, SE; Gradner, G; Knödl, K; Tichy, A; Rütgen, BC; Beham-Schmid, C

Title: World Health Organisation Classification of Lymphoid Tumours in Veterinary and Human Medicine: a Comparative Evaluation of Gastrointestinal Lymphomas in 61 Cats.

Source: J Comp Pathol. 2018; 159:1-10

Authors Vetmeduni Vienna:

Fuchs-Baumgartinger Andrea
Gradner Gabriele
Hammer Sabina
Rütgen Barbara
Tichy Alexander
Wolfesberger Birgitt

Vetmed Research Units
Clinical Pathology Platform
University Clinic for Small Animals, Clinical Unit of Internal Medicine Small Animals
University Clinic for Small Animals, Clinical Unit of Small Animal Surgery
Institute of Immunology
Institute of Pathology
Platform Bioinformatics and Biostatistics

To diagnose and classify the various entities of lymphomas, the World Health Organisation (WHO) classification is applied in human as well as in veterinary medicine. We validated the concordance of these classification systems by having a veterinary and human pathologist evaluate gastrointestinal lymphoma tissue from 61 cats. In 59% of all cases, there was a match between their respective diagnoses of the lymphoma subtype. A complete consensus between the two evaluators was obtained for all samples with a diagnosis of diffuse large B-cell lymphoma, T-cell anaplastic large cell lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. A corresponding diagnosis was also made in the majority of samples with enteropathy associated T-cell lymphoma (EATL) type II, although this subtype in cats has similarities to the 'indolent T-cell lymphoproliferative disorder of the gastrointestinal tract', a provisional entity newly added to the revised human WHO classification in 2016. Very little consensus has been found with cases of EATL type I due to the fact that most did not meet all of the criteria of human EATL I. Hence, the human pathologist assigned them to the heterogeneous group of peripheral T-cell lymphomas (not otherwise specified). Consequently, concrete guidelines and advanced immunophenotyping based on the model of human medicine are essential to differentiate these challenging entities in veterinary medicine.Copyright © 2017 Elsevier Ltd. All rights reserved.

Keywords Pubmed: Animals
Cat Diseasesclassificationpathology
Gastrointestinal Neoplasmsveterinary
World Health Organization

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