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Publication type: Journal Article
Document type: Full Paper

Year: 2018

Author(s): Pashkovskaya, AA; Vazdar, M; Zimmermann, L; Jovanovic, O; Pohl, P; Pohl, EE

Title: Mechanism of Long-Chain Free Fatty Acid Protonation at the Membrane-Water Interface.

Source: Biophys J. 2018; 114(9):2142-2151



Authors Vetmeduni Vienna:

Jovanovic Olga
Pashkovskaya Alina
Pohl Elena
Zimmermann Lars

Vetmed Research Units
Institute of Physiology, Pathohysiology and Biophysics, Unit of Physiology and Biophysics


Project(s): Mechanism of nucleotide-mediated inhibition of mitochondrial uncoupling proteins


Abstract:
Long-chain free fatty acids (FFAs) play an important role in several physiological and pathological processes such as lipid fusion, adjustments of membrane permeability and fluidity, and the regulation of enzyme and protein activities. FFA-facilitated membrane proton transport (flip-flop) and FFA-dependent proton transport by membrane proteins (e.g., mitochondrial uncoupling proteins) are governed by the difference between FFA"s intrinsic pK


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