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Selected Publication:

Type of publication: Journal Article
Type of document: Full Paper

Year: 2018

Authors: Hartmann, C; Gerner, W; Walter, I; Saalmüller, A; Aurich, C

Title: Influences of intrauterine semen administration on regulatory T lymphocytes in the oestrous mare (Equus caballus).

Source: Theriogenology. 2018; 118:119-125

Authors Vetmeduni Vienna:

Aurich Christine
Gerner Wilhelm
Hartmann Constanze
Saalmüller Armin
Walter Ingrid

Vetmed Research Units
Insemination and Embryotransfer Platform
Institute of Immunology
Institute of Pathology

In the mare, early pregnancy loss is common, but involvement of the maternal immune system in the pathogenesis of this condition has not been investigated in detail so far. In the present study, we assessed effects of exposure of the endometrium to semen or seminal plasma in oestrous mares on the response of regulatory T lymphocytes (Tregs) in the peripheral circulation as well as in the endometrium. Raw semen, seminal plasma or PBS (control) were introduced into the uterus of oestrous mares (n = 12). Blood was collected immediately before insemination or PBS infusion (time 0), and 12, 24 and 48 h thereafter. Endometrial biopsies were collected at 24 h. In peripheral blood, Treg (CD4

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