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Type of publication: Journal Article
Type of document: Full Paper

Year: 2018

Authors: Hille, K; Felski, M; Ruddat, I; Woydt, J; Schmid, A; Friese, A; Fischer, J; Sharp, H; Valentin, L; Michael, GB; Hörmansdorfer, S; Messelhäußer, U; Seibt, U; Honscha, W; Guerra, B; Schwarz, S; Rösler, U; Käsbohrer, A; Kreienbrock, L

Title: Association of farm-related factors with characteristics profiles of extended-spectrum β-lactamase- / plasmid-mediated AmpC β-lactamase-producing Escherichia coli isolates from German livestock farms.

Source: Vet Microbiol. 2018; 223:93-99

Authors Vetmeduni Vienna:

Käsbohrer Annemarie

Vetmed Research Units
Institute of Food Safety, Food Technology and Veterinary Public Health, Unit of Veterinary Public Health and Epidemiology

Resistance to β-lactam antibiotics, including third-generation cephalosporins, is of major concern for animal and human health. In this study, extended-spectrum β-lactamase (ESBL) / plasmid-mediated AmpC (pAmpC) β-lactamase -producing Escherichia coli isolates from German livestock farms were characterised and associations of these isolate characteristics with farm-related factors were investigated across different types of livestock. A total of 469 isolates originating from 150 farms (34 broiler farms, 38 fattening pig farms, 43 dairy cattle farms, 35 beef cattle farms) was included in the analyses. ESBL-gene family, phylogroup and phenotypic antimicrobial susceptibility for several antimicrobial agents were determined. This data was used to define different profiles characterising the isolates. Multivariate analyses using a distance-based non-parametric approach were performed to investigate associations between the profiles of the isolates and farm-related factors (e.g. management, husbandry, and environment of the farms). Co-occurrence of ESBL-gene families were not found in any of the isolates analysed. Sixty-eight percent of the isolates carried bla

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