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Publication type: Journal Article
Document type: Full Paper

Year: 2018

Author(s): Bauer, T; Sipos, W; Stark, TD; Käser, T; Knecht, C; Brunthaler, R; Saalmüller, A; Hofmann, T; Ehling-Schulz, M

Title: First Insights Into Within Host Translocation of the Bacillus cereus Toxin Cereulide Using a Porcine Model.

Source: Front Microbiol. 2018; 9:2652



Authors Vetmeduni Vienna:

Bauer Tobias
Brunthaler Rene
Ehling-Schulz Monika
Käser Tobias
Knecht Christian
Saalmüller Armin
Sipos Wolfgang

Vetmed Research Units
Institute of Microbiology, Functional Microbiology Division
Institute of Immunology
Institute of Pathology
University Clinic for Swine


Abstract:
Bacillus cereus is a gram-positive pathogen mainly known to evoke two types of foodborne poisonings. The diarrheal syndrome is caused by enterotoxins produced during growth in the intestine. In contrast, the emetic type is caused by the dodecadepsipeptide cereulide pre-formed in food. Usually, both diseases are self-limiting but occasionally more severe forms, including fatal ones, are reported. Since the mechanisms of cereulide toxin uptake and translocation within the body as well as the mechanism of its toxic action are still unknown, we used a porcine model to investigate the uptake, routes of excretion and distribution of cereulide within the host. Pigs were orally challenged with cereulide using single doses of 10-150 μg cereulide kg


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