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Publication type: Journal Article
Document type: Full Paper

Year: 2019

Author(s): Grilz-Seger, G; Druml, T; Neuditschko, M; Dobretsberger, M; Horna, M; Brem, G

Title: High-resolution population structure and runs of homozygosity reveal the genetic architecture of complex traits in the Lipizzan horse.

Source: BMC Genomics. 2019; 20(1):174



Authors Vetmeduni Vienna:

Brem Gottfried
Dobretsberger Maximilian
Druml Thomas
Grilz-Seger Gertrud

Vetmed Research Units
Unit of Reproductive Biology


Project(s): Automatisation der Phänotypisierungen von Exterieur-und Bewegungsmerkmalen und genomische Analysen beim Lipizzaner


Abstract:
The sample ascertainment bias due to complex population structures remains a major challenge in genome-wide investigations of complex traits. In this study we derived the high-resolution population structure and levels of autozygosity of 377 Lipizzan horses originating from five different European stud farms utilizing the SNP genotype information of the high density 700 k Affymetrix Axiom™ Equine genotyping array. Scanning the genome for overlapping runs of homozygosity (ROH) shared by more than 50% of horses, we identified homozygous regions (ROH islands) in order to investigate the gene content of those candidate regions by gene ontology and enrichment analyses.


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