University of Veterinary Medicine Vienna - Research portal

Diagrammed Link to Homepage University of Veterinary Medicine, Vienna

Selected Publication:

Open Access Logo

Type of publication: Journal Article
Type of document: Full Paper

Year: 2019

Authors: Grilz-Seger, G; Druml, T; Neuditschko, M; Dobretsberger, M; Horna, M; Brem, G

Title: High-resolution population structure and runs of homozygosity reveal the genetic architecture of complex traits in the Lipizzan horse.

Source: BMC Genomics. 2019; 20(1):174

Authors Vetmeduni Vienna:

Brem Gottfried
Dobretsberger Maximilian
Druml Thomas
Grilz-Seger Gertrud

Vetmed Research Units
Institute of Animal Breeding and Genetics, Unit of Reproductive Biology

Project(s): Automatisation der Phänotypisierungen von Exterieur-und Bewegungsmerkmalen und genomische Analysen beim Lipizzaner

Genetic analyses of coat colors with regard to practical breeding andconservation genetics in the Lipizzan, Noriker horse breed and theWeiße Barockesel breed

The sample ascertainment bias due to complex population structures remains a major challenge in genome-wide investigations of complex traits. In this study we derived the high-resolution population structure and levels of autozygosity of 377 Lipizzan horses originating from five different European stud farms utilizing the SNP genotype information of the high density 700 k Affymetrix Axiom™ Equine genotyping array. Scanning the genome for overlapping runs of homozygosity (ROH) shared by more than 50% of horses, we identified homozygous regions (ROH islands) in order to investigate the gene content of those candidate regions by gene ontology and enrichment analyses.

© University of Veterinary Medicine ViennaHelp and Downloads