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Publication type: Journal Article
Document type: Full Paper

Year: 2019

Author(s): Rodríguez-Gómez, IM; Talker, SC; Käser, T; Stadler, M; Reiter, L; Ladinig, A; Milburn, JV; Hammer, SE; Mair, KH; Saalmüller, A; Gerner, W

Title: Expression of T-Bet, Eomesodermin, and GATA-3 Correlates With Distinct Phenotypes and Functional Properties in Porcine γδ T Cells.

Source: Front Immunol. 2019; 10:396



Authors Vetmeduni Vienna:

Gerner Wilhelm
Hammer Sabina
Käser Tobias
Ladinig Andrea
Mair Kerstin
Milburn Jemma
Reiter Lisa
Rodriguez Gomez Irene Magdalena
Saalmüller Armin
Stadler Maria
Talker Stephanie

Vetmed Research Units
Institute of Immunology
University Clinic for Swine


Project(s): CD Laboratory for an optimized prediction of vaccination success in pigs


Abstract:
Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional differentiation, but their expression has not been investigated in porcine γδ T cells so far. We analyzed the expression of these transcription factors in γδ thymocytes, mature γδ T cells from blood, spleen, lymph nodes, and lung tissue as well as in vitro stimulated γδ T cells on the protein level by flow cytometry. GATA-3 was present in more than 80% of all γδ-thymocytes. Extra-thymic CD2


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