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Publication type: Journal Article
Document type: Full Paper

Year: 2019

Author(s): Felkel, S; Wallner, B; Chuluunbat, B; Yadamsuren, A; Faye, B; Brem, G; Walzer, C; Burger, PA

Title: A First Y-Chromosomal Haplotype Network to Investigate Male-Driven Population Dynamics in Domestic and Wild Bactrian Camels.

Source: Front Genet. 2019; 10:423



Authors Vetmeduni Vienna:

Brem Gottfried
Burger Pamela
Felkel Sabine
Wallner Barbara
Walzer Christian

Vetmed Research Units
Research Institute of Wildlife Ecology, Conservation Medicine
Research Institute of Wildlife Ecology
Institute of Animal Breeding and Genetics, Unit of Molecular Genetics
Institute of Animal Breeding and Genetics, Unit of Reproductive Biology


Project(s): Characterization of the immunogenome in Old World camelids

Characterisation of stallion lines in Austria horse breeds with Y-chromosomal markers


Abstract:
Polymorphic markers on the male-specific part of the Y chromosome (MSY) provide useful information for tracking male genealogies. While maternal lineages are well studied in Old World camelids using mitochondrial DNA, the lack of a Y-chromosomal reference sequence hampers the analysis of male-driven demographics. Recently, a shotgun assembly of the horse MSY was generated based on short read next generation sequencing data. The haplotype network resulting from single copy MSY variants using the assembly as a reference revealed sufficient resolution to trace individual male lines in this species. In a similar approach we generated a 3.8 Mbp sized assembly of the MSY of Camelus bactrianus. The camel MSY assembly was used as a reference for variant calling using short read data from eight Old World camelid individuals. Based on 596 single nucleotide variants we revealed a Y-phylogenetic network with seven haplotypes. Wild and domestic Bactrian camels were clearly separated into two different haplogroups with an estimated divergence time of 26,999 ± 2,268 years. Unexpectedly, one wild camel clustered into the domestic Bactrian camels" haplogroup. The observation of a domestic paternal lineage within the wild camel population is concerning in view of the importance to conserve the genetic integrity of these highly endangered species in their natural habitat.


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