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Type of publication: Journal Article
Type of document: Full Paper

Year: 2019

Authors: Desvars-Larrive, A; Ruppitsch, W; Lepuschitz, S; Szostak, MP; Spergser, J; Feßler, AT; Schwarz, S; Monecke, S; Ehricht, R; Walzer, C; Loncaric, I

Title: Urban brown rats ( Rattus norvegicus ) as possible source of multidrug-resistant Enterobacteriaceae and meticillin-resistant Staphylococcus spp., Vienna, Austria, 2016 and 2017.

Source: Euro Surveill. 2019; 24(32): pii=1900149.



Authors Vetmeduni Vienna:

Desvars Amelie
Loncaric Igor
Spergser Joachim
Szostak Michael
Walzer Christian

Vetmed Research Units
Research Institute of Wildlife Ecology, Conservation Medicine
Institute of Microbiology



Abstract:
BackgroundBrown rats ( Rattus norvegicus ) are an important wildlife species in cities, where they live in close proximity to humans. However, few studies have investigated their role as reservoir of antimicrobial-resistant bacteria.AimWe intended to determine whether urban rats at two highly frequented sites in Vienna, Austria, carry extended-spectrum β-lactamase-producing Enterobacteriaceae , fluoroquinolone-resistant Enterobacteriaceae and meticillin-resistant (MR) Staphylococcus spp. (MRS).MethodsWe surveyed the presence of antimicrobial resistance in 62 urban brown rats captured in 2016 and 2017 in Vienna, Austria. Intestinal and nasopharyngeal samples were cultured on selective media. We characterised the isolates and their antimicrobial properties using microbiological and genetic methods including disk diffusion, microarray analysis, sequencing, and detection and characterisation of plasmids.ResultsEight multidrug-resistant Escherichia coli and two extensively drug-resistant New Delhi metallo-β-lactamases-1 (NDM-1)-producing Enterobacter xiangfangensis ST114 ( En. cloacae complex) were isolated from nine of 62 rats. Nine Enterobacteriaceae isolates harboured the bla


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