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Selected Publication:

Type of publication: Journal Article
Type of document: Review Article

Year: 2020

Authors: Barghi, N; Hermisson, J; Schlötterer, C

Title: Polygenic adaptation: a unifying framework to understand positive selection.

Source: Nat Rev Genet. 2020 21 (12) 769-781.



Authors Vetmeduni Vienna:

Barghi Neda
Schlötterer Christian

Vetmed Research Units
Institute of Population Genetics


Project(s): Wolbachia infection Dynamics in evolving Drosophila populations

Interference of adaptive gene expression by experim. evolution

Population Genetics


Abstract:
Most adaption processes have a polygenic genetic basis, but even with the recent explosive growth of genomic data we are still lacking a unified framework describing the dynamics of selected alleles. Building on recent theoretical and empirical work we introduce the concept of adaptive architecture, which extends the genetic architecture of an adaptive trait by factors influencing its adaptive potential and population genetic principles. Because adaptation can be typically achieved by many different combinations of adaptive alleles (redundancy), we describe how two characteristics - heterogeneity among loci and non-parallelism between replicated populations - are hallmarks for the characterization of polygenic adaptation in evolving populations. We discuss how this unified framework can be applied to natural and experimental populations.


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