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Type of publication: Journal Article
Type of document: Full Paper

Year: 2021

Authors: Vogl, C; Mikula, LC

Title: A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection.

Source: Theor Popul Biol. 2021; 139:1-17

Authors Vetmeduni Vienna:

Vogl Claus

Vetmed Research Units
Institute of Animal Breeding and Genetics, Unit of Molecular Genetics

Project(s): Population Genetics

In this article, a biallelic reversible mutation model with linear and quadratic selection is analysed. The approach reconnects to one proposed by Kimura (1979), who starts from a diffusion model and derives its equilibrium distribution up to a constant. We use a boundary-mutation Moran model, which approximates a general mutation model for small effective mutation rates, and derive its equilibrium distribution for polymorphic and monomorphic variants in small to moderately sized populations. Using this model, we show that biased mutation rates and linear selection alone can cause patterns of polymorphism within and substitution rates between populations that are usually ascribed to balancing or overdominant selection. We illustrate this using a data set of short introns and fourfold degenerate sites from Drosophila simulans and Drosophila melanogaster.Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

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